Jagadguru Sri Shivarathreeshwara University

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TIFAC CORE Herbal Drugs

Technology Information, Forecasting and Assessment Council (TIFAC) has been carrying out Mission and Programs under the Technology Vision 2020 projects. One of these missions, code names REACH (Relevance and Excellence in ACHieving new heights in educational institutions), aims at upgrading select science and engineering college, in the country as “Centres of Relevance and Excellence (CORE)” to broaden the level of education and meet the scientific technological manpower requirements of India in advanced areas promising to show-up on the horizon in the years to come.

The Apex Committee appointed by TIFAC selected JSS College of Pharmacy, Ooty, to locate a CORE in Herbal Drugs under the TIFAC, MISSION REACH Projects. The TIFAC CORE in Herbal Drugs has been functioning since January 2001. As per the mandate entrusted to JSS College of Pharmacy, Ootacamund, by TIFAC, Department of Science and Technology, Govt. of India, the major objective of the TIFAC-Centre of Relevance and Excellence in Herbal Drugs is to undertake research programmes for the Indian industries engaged in manufacturing Herbal Drugs/Traditional Medicinal Products in addition to meet the specialized demands of human resource requirements of these industries.

Specific Objectives of TIFAC CORE in HD

To function as a skill-development centre for all stake holders of natural products
To serve as a training/knowledge centre for empowering tribal youth to sustain indigenous tribal/folk medicine
To serves as a consultant for natural product industry and regulatory needs at various capacities
To design and offer new academic (industry relevant) programme
To become an international leader in natural product research & development

Key Milestones & Impact of TIFAC CORE- HD

“HAPENZ”, a polyherbal syrup formulation (natural appetizer) for children was developed and the technology transferred to our industrial partner. The product was commercialized by M/S TABLETS INDIA Ltd., Chennai and it is well received by the market.
“NSF-3”, a polyherbal tablet formulation for sleep was developed and the technology was transferred to our industrial partner, TABLETS INDIA Ltd., Chennai. It has been commercialized.
The centre has filed five patents to its credit, out of which two have been granted.
The centre has published ~100 scientific papers in indexed journals and presented 300 scientific papers in International /International / National Seminars / Conferences. (H index and other citation metrics)

A book “ENGAL KUDUMBA MARUTHUVAM” authored by Mrs. A.P.J. Nazeema Begum was published by TIFAC CORE-HD. The book describes the herbal remedies used by the forefathers of Dr. APJ Abdul Kalam.
TIFAC CORE in HD faculties authored a handbook that carries information on 300 medicinal plants of Nilgiris Biosphere, namely “Medicinal Plants Information Hand Book” published in association with Nilgiris Medicinal Plant Promoters’ Society, Ooty.
Twenty-five (25) research scholars have obtained their doctoral degree in Phytopharmacy (Ph.D) and they were well placed either in industries, academic institutions or contract research laboratories in India and abroad.
The centre has been conducting an M.Pharm., programme in Phytopharmacy & Phytomedicine. Twelve (12) batches of students (108) have successfully graduated and well employed in various industries and institutions.
A Diploma programme in ‘Production and Quality Control of Medicinal Plants’, conducted in collaboration with Tamil Nadu Agriculture University, Coimbatore, and 13 students have graduated under this programme

Awards and Recognition

Recently, Re:Think INDIA, a Nationalist think tank has conferred upon JSS College of Pharmacy, Ootacamund, the Bharat RatnaAtalBihari Vajpayee Award for Innovation 2017, on May 11, 2017, the National Technology Day, at India International Centre, New Delhi, for the patented Herbal Drugs, namely Hapenz& NSF-3 developed by TIFAC Centre of Relevance and Excellence in Herbal Drugs, JSS College of Pharmacy, Ootacamund and marketed by M/s Tablets (India) Ltd., Chennai.

International Seminars/Workshops/Symposium organised (Selective)

2019:Knowledge Exchange Forum on Nigiri’s Biosphere Reserve Conservation: The TIFAC CORE in Herbal Drugs, JSS College of Pharmacy, Ooty had organised a “Knowledge Exchange Forum on Nigiri’s Biosphere Research Conservation on 5th Feb 2019. In this event, the president of Scientific Committee for Problem of Environment (SCOPE), Prof. Jan Samseth from Norway and the Former Director of Division of Ecological and Earth Sciences, UNESCO, Prof. Natarajan Ishwaran from China were attended to brief the objectivities and activities of SCOPE and their aspiration to establish a nodal centre in India. Prof. James C. Griffith, Scientific Advisor of Responsible Clinical Nutrition, USA and adjunct faculty of JSS Academy of Higher Education & Research, Mysuru had congratulated both JSS & SCOPE for their timely initiatives on addressing environmental issues. Dr. M. Sureshkumar, the co-ordinator of TIFAC CORE in HD, Department of Pharmacognosy delivered a lecture on the journey and its impact of the various initiatives of JSS to support Nilgiri’sbioconservation, including scientific expertise on regional medicinal plants, tribal empowerment and sustainable eco-system. The members and representatives of local interest groups including AYUSH, Tribal Research Centre, Govt. Arts College, C.P.R Environment Education Centre were activity participated in the discussion and shared their experience with regional environment and eco-system.

2018:Aiming to provide an intense training on one of the emerging gene editing tools, CRISPR-CAS at research level for academic and industrial researchers, a two-day workshop on “Gene editing using “CRISPR-CAS”: hands-on training on its basics and applications in drug discovery” held during December 13-14, 2018 at JSS College of Pharmacy, Ooty, Tamil Nadu. During the inauguration, the chief guest felicitated JSSCP alumni Mr.Muthuswamy (Samy) Shanmugam, the Founder and President of Novitium Pharma, USA as an “Outstanding Entrepreneur” and Dr. Nirmal Robinson, Senior Research Fellow and Head, Centre for Cancer Biology, University of South Australia, Australia, as an Outstanding Researcher ”

2017: An International Seminar and Exhibition on Phytopharmaceuticals: Emerging Challenges and Opportunities was held on 11-12 December 2017 at JSS College of Pharmacy, Ooty

2012: Indo-South Africa Workshop on “Traditional Medicine System: Sharing Knowledge and Experience” was held on 29-31 October 2012 at the JSS College of Pharmacy, Ooty.

2009: A five-day workshop on “Plant Nutraceuticals and Bioactive Molecules: A growth opportunity for the Pharmaceutical Industry in Australia and India”, a collaborative activity between Sydney University and J.S.S. College of Pharmacy was held during June 2-6, 2009 at J.S.S. College of Pharmacy, under Indo-Australian Strategic Research Fund.

2007: The Second Indo-Canadian conference on Natural Products was held during February 24-26, 2007 along with the International Conference in Pharmaceutical Sciences, Technology and Practice at JSS College of Pharmacy, Ooty.

Global Affairs: TIFAC CORE in HD has been recognized as an official partner with International Natural Product Sciences Task Force, Europe

Networking Outcomes

Exhibition:TIFAC CORE in HD exhibited PHARMAC South 2018 at Chennai Trade Centre, organised by India Drug Manufacturer’s Association on 6th-7th July 2018 which attracted small-mid scale Pharma industries and consultancy services.
Outcome: Attending this event helped to link with industries.

VISIT TO SANOFI SYNTHELABO FACILITY, VERNA, GOA

Dr. S. P. Dhanabal, Principal, Dr. Suresh K. Mohankumar, Research Director and Dr. N. Krishna veni, Professor & Head, Department of Pharmaceutical Analysis, JSS College of Pharmacy, Ooty visited Sanofi Synthelabo Development Centre, Goa to strategically discuss on potential collaborations and facility sharing for the benefits of the industry, Academic Colleagues and also students on 6th August 2018.
Outcome:Students/Scholar exchange projects

Visit to DRF, New Delhi

The co-ordinator visited the senior management team, COO: Dr. Manu Jaggi, CSO: Dr. Anu and Head, Pharmacology: Mr. Kamaraj (JSSCP, Alumni) to discuss the collaborative projects. We have identified that a) phytochemical characterisation and b) biodistribution studies with In vivo animal imager are the potential projects could be initiated. We have agreed with the timeline preparing and signing CDA and MOU to pursue the associations further.
Outcome: CDA signed, Consultancy projects for phytochemical characterisation in pipeline.

Mr. Bob Sandhu visit to JSSCP, Ooty The owner of M/S Sandhu Products Inc, USA and our alumni Mr. Bob Sandu had visited JSS College of Pharmacy to discuss various phyto-projects and contract research services requirements. This meeting was attended by all head of the departments, principal and others.
Outcome: The CDA was signed and currently one proposal has been submitted to M/S Sandhu Products Inc, USA for their review and consideration

International Fellowships

Sl #	Name & Affiliation	Fellowship & Duration	Project Description
1	Dr. BEDIKOU Ehuie Micael Lecturer (Assistant Professor) Food Biotechnology and Enzymology. University Felix HOUPHOUET-BOIGNY, Abidjan Ivory Coast	CV Raman Fellow Feb- Aug 2018	Isolation of peptides from germinating Amaranthus hybridus seeds for the regulation of hypertension, diabetes and obesity
2	Dr. DOUMBIA Idrissa (Associate Professor) Biochemistry-Pharmacology University Felix HOUPHOUET-BOIGNY, Abidjan/University of Man Ivory Coast	CV Raman Fellow Mar-May 2018	Phytochemical and pharmacological studies of Entadrophragma angolense and Entada mannii 2 ivorian antidiabetic medicinal plants
3	Mr. Awotunde Oluwasegum Samson Lecturer, Biochemistry Habib Medical school, Islamic International University, Uganda	NAM S&T fellowship Aug-2017 to Jan 2018	Pharmacological screening of terminalia species for its antioxidant, anticancer and aprodhisiac activity
4	Mr. Andre Ndagijimana National Industrial development agency Ruwanda	NAM S&T fellowship Jan- July 2016	Development and standardisation of an antitussive formulation.
5	Mr. Adewale Michael ESAN Nutritional and Industrial Biochemistry, University of Ibadan Nigeria	INSA JRD TATA Feb- May 2016	Antihyperlipidemic and glucose lowering effect of hydroalcoholic extract of bioregulator treated okra (Abelmoschus esculentus).
6	Ms Tanya Denne Oregon Health and Science University Portland	Self Dec 2015- Feb 2016	Traditional documentation and collection of Mucuna purirens

State-of-the-art facilities and strengths

Expert researchers in basic, translational and clinical research
Medicinal plant garden, herbarium and plant extract library/inventory
Well-equipped pharmacognostical and phytochemical facility
Approved analytical and testing laboratories
Well-equipped tissue culture and animal pharmacology/toxicology labs
Formulation and new product development
Regulatory and document preparation assistance to industries

S.No	List of Major Equipment
1	Freeze dryer
2	Fermenter
3	Incinerator
4	HPLC System
5	Viscometer
6	Blister Packing Machine
7	PCR Machine
8	Fluorescence Microscope
9	Extruder + Spheroidiser
10	LCMS
11	Tablet Dissolution Tester
12	Cell Analyser
13	Fluidised Bed Processor
14	HPTLC
15	GC
16	Cyclograph
17	Flash Chromatography
18	Rotary evaporator

Our Industrial Partners

M/s Tablets (India) Ltd., Chennai, is one of the Jhaver Group of companies whose turnover today is Rs.350/- Crores. The company has tie-ups with Japan and Switzerland and it deals in prescription drugs, generic drugs and drugs for export. A quarter of its turnover comes from exports alone. It has unique formulations based on amino acid nutraceuticals end products, meant for GI related problems. Recently, the company has expanded its activity in the area of herbal drugs and is a partnering industry of TIFAC CORE in Herbal Drugs. The company looks to introducing herbal drugs for the treatment of chronic ailments such as hypertension, arthritis and metabolic disorders.

Apex Laboratories, Chennai, established in 1978 launched for the first time in India, a zinc-based product, ‘Zincofer’ and in quick succession became the pioneers in the use of Zinc in pharmaceutical formulations. At present Apex has a fully automated modern manufacturing complex, conforming to WHO-GMP standards with a turnover in Rs. 700 million. Next in line to be launched are Ayurvedic products. Apex is also into nutraceuticals aimed at providing relief to patients from osteoarthritis with products such as Caravit and Sulfovit. The company has also under its control about 1600 acres of Private Reserve Forest in Agastia Hills in Tirunelveli District of Tamil Nadu in South India, which is being surveyed for identifying the plants of medicinal value. Several herbal products launched by the company have been already subjected to efficacy and toxicity studies at TIFAC CORE HD. Techniques have been evolved for the standardization of the individual ingredients of the herbal extracts used in the polyherbal formulations to conform the authenticity, purity and quality of the products.

*Apart from the above partners, we have rendered project consultancies and trainings to various phytopharmaceutical industries and institutions. Please refer to TIFAC REPORT for further details.

We welcome both national and international collaborative opportunities and ventures

Please feel free to write to us should you need further information about TIFAC CORE-HD activities and capabilities.

Best regards

Dr. Shanmugam Ramaswamy, M.Pharm, Ph.D, DPM, PGDPL (Nalsar), FAGE
Coordinator- TIFAC CORE in Herbal Drugs
JSS College of Pharmacy
Rocklands, Udhagamandalam - 643 001 Tamilnadu, India
Phone: +91 9843454943
Email: shanmugamr@jssuni.edu.in