“Centre of Excellence in Nanoscience & Technology” was inaugurated by our beloved principal Dr. SP Dhanabal, JSS College of Pharmacy, Ooty on September, 2019 to enhance advanced advanced research in the areas of Nanoscience and Nanotechnology, to promote, develop and binding interdisciplinary research activities, to conduct training and awareness programs, workshops national and international conferences on recent trends and developments of nanoscience on various themes of national interests. Also the center shall research and development projects from various government agencies and offer consultancy services to industries and research organizations in India and abroad.
JSS Academy of Higher Education & Research, Mysuru
| Title | Authors Name | Journal | Year | Collaborator | IF |
|---|---|---|---|---|---|
| Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis. | Kaur G, Singh SK, Kumar R, Kumar B, Kumari Y, Gulati M, Pandey NK, Gowthamarajan K, Ghosh D, Clarisse A, Wadhwa S. | Journal of Drug Delivery Science and Technology | 2020 | Lovely Professional University, Punjab. University of Technology Sydney, Australia NIPER, Hyderabad, India Macquarie University, Australia | 2.734 |
| Effect of co-administration of probiotics with guar gum, pectin and eudragit S100 based colon targeted mini tablets containing 5-Fluorouracil for site specific release | Kumar A, Gulati M, Singh SK, Gowthamarajan K, Prashar R, Mankotia D, Gupta JP, Banerjee M, Sinha S, Awasthi A, Corrie L. | Journal of Drug Delivery Science and Technology | 2020 | Lovely Professional University, Punjab. | 2.734 |
| Fail-safe nano-formulation of prodrug of sulfapyridine: Preparation and evaluation for treatment of rheumatoid arthritis. | Kapoor B, Gulati M, Singh SK, Khatik GL, Gupta R, Kumar R, Kumar R, Gowthamarajan K, Mahajan S, Gupta S. | Materials Science and Engineering: C | 2021 | Fortis Hospital, Punjab Lovely Professional University, Punjab. | 5.88 |
| Opening eyes to therapeutic perspectives of bioactive polyphenols and their nanoformulations against diabetic neuropathy and related complications | Rubiya Khursheed, Sachin Kumar Singh, Sheetu Wadhwa, Monica Gulati, Bhupinder Kapoor, Ankit Awasthi, Arya Kr, Rajan Kumar, Faheem Hyder Pottoo, Vijay Kumar, Harish Dureja, Krishnan Anand, Dinesh Kumar Chellappan, Kamal Dua & K. Gowthamarajan | Expert Opinion on Drug Delivery | 2020 | Lovely Professional University, Punjab. International Medical University, Malaysia University of free state, South Africa University of Technology Sydney, Australia | 4.838 |
| Bite-sized review on advance delivery system, support in the management of covid-19. | Kothandan S, Venkatesan A, Radhakrishnan A, Reddy KV, Kuppusamy G, Dhanabal SP, Balasubramanian S, Bhojraj S. | International Journal of Research in Pharmaceutical Sciences. | 2020 | - | - |
Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis.
The objective of study was to develop modified apple polysaccharide (MAP) based silver nanoparticles (AgNPs) loaded with mesalamine (MES) for effective treatment of ulcerative colitis in acetic acid induced rat model. AgNPs were prepared by reducing silver nitrate using MAP solution. The size and zeta potential of AgNPs was 89 ± 3 nm and −16.3 ± 1.54 mV and AgNPs loaded with MES (AgNPs-MES) was 101 ± 9 nm and −14.27 ± 2.16 mV. The dissolution study revealed about 54% drug release after 5 h indicating release of drug at the colonic site. The in vivo study was carried out on acetic acid induced ulcerative colitis rats and efficacy of treatment was assessed through evaluation of disease activity index and level of antioxidants as well as tumor necrosis factor-α after 7th and 14th day of induction of colitis. Histopathological evaluation of colonic tissue was also carried out. The results revealed that AgNPs-MES (high dose) provided better therapeutic efficacy for the treatment of UC as compared to its low dose, MES alone, MES-MAP, AgNPs alone and MAP alone. It was concluded that MAP based AgNPs loaded with MES were successfully formulated and found to be effective in treating ulcerative colitis.
Effect of co-administration of probiotics with guar gum, pectin and eudragit S100 based colon targeted mini tablets containing 5-Fluorouracil for site specific release
Oral colon targeted mini-tablets containing 5-Fluorouracil (5-FU) were developed by using guar gum, pectin and Eudragit S100. Probiotics were co-administered to constantly replenish the gut microflora of colon that gets damaged due to pathophysiology of cancer and side effect of 5-FU. Replacement of microbial count ensures that the polysachharide used for sustaining the drug release gets digested to release the drug, once the formulation reaches the colon. The site-specific release of coated tablets was confirmed by dissolution studies in medium containing rat caecal contents (RCC), wherein, the formulation containing Eudragit S100, pectin and guar gum in the ratio of 04:03:03 w/w, showed less than 10% drug release in initial 5 h and immediate burst release (100%) between 5th to 10th hour. The cell line studies carried for pooled dissolution samples indicated that more than 90% cells were viable in all the cases till 5th hour. Significant (p < 0.05) decline in cellular viability was observed in case of coated mini tablets as compared to un-coated one. The pharmacokinetic studies showed a lower as well as delayed plasma concentration in the coated formulations endorsing the original hypothesis of reduction in drug exposure of the non-target sites.
Fail-safe nano-formulation of prodrug of sulfapyridine: Preparation and evaluation for treatment of rheumatoid arthritis.
Aim of the present study was to give a second life to the long-abandoned drug, sulfapyridine (SP) for its anti-arthritic potential by design of nano-vesicular delivery system. For this, intra-articular delivery of its liposomal formulation was tried. As the prepared formulation exhibited rapid drug leakage, an arthritis responsive prodrug of SP showing lability towards synovial enzymes was synthesized to exploit the over-expression of arthritis specific enzymes. Prodrug (SP-PD) exhibited better retention in liposomes as compared to the drug, preventing its escape from synovium. Hydrolysis of SP-PD in human plasma and synovial fluid indicated its high susceptibility to enzymes. The liposomes of SP-PD exhibited larger mean size, less PDI and higher zeta potential as compared to those for SP liposomes. In arthritic rats, prodrug liposomes were found to reverse the symptoms of inflammation, including the levels of biochemical markers. Liposomes of bio-responsive prodrug, therefore, offer a revolutionary approach in the treatment of rheumatoid arthritis.
Opening eyes to therapeutic perspectives of bioactive polyphenols and their nanoformulations against diabetic neuropathy and related complications
In this review various polyphenol based nanoformulations such as nanospheres, self-nanoemulsifying drug delivery systems, niosomes, electrospun nanofibers, metallic nanoparticles explored exclusively to treat DN are discussed. However, the literature available related to polyphenol based nanoformulations to treat DN is limited. Moreover, these experiments are limited to preclinical studies. Hence, more focus is required towards development of nanoformulations using simple and single step process as well as inexpensive and non-toxic excipients so that a stable, scalable, reproducible and non-toxic formulation could be achieved and clinical trials could be initiated.
Bite-sized review on advance delivery system, support in the management of covid-19.
COVID-19 are an unprecedented challenge for healthcare providers; there are no approved treatments for this disease, nor are there no approved vaccines. The sources of infection of novel coronavirus detected mainly from animals to humans or infected human to healthy human through respiratory droplets and long contact period are the most prominent way of transmission. Coronaviruses are structurally large-sized single-stranded RNA viruses. The capability of regular therapies is constantly fading away exactly in case of coronavirus due to the modification of new strain, which could be certainly due to speedy adaptation in a protein sequence. The scientist should understand the pandemic situation of virus infection, also as they ought to identify the newest pathway research to regulate the virus infection. Developing new and smart strategies for drugs already in the development pipeline or already exiting drug can be treating diseases in patients could be useful to ϑight against COVID-19. In the last few years, several new smart drug delivery approaches made the changeover from the laboratory development to clinical applications. At present technology, researchers provide effective and low toxicity drug delivery when compared with classical delivery. This approach will be a great opportunity for the scientist to work and update preclinical research of advance drug delivery systems to cloneable and convertible production to the human trial success rate. In conclusion, by understanding the new drug delivery research approaches for antiviral therapy are increases to produce safe and high-quality therapies at reasonable costs.
| S. no | Title of the Patent | Patent/Application No. | Name of Inventors | Department | Details of different stages | Current Status | Applicant name |
|---|---|---|---|---|---|---|---|
| 1 | Method of Processing Nanoemulsion gel comprising terbinafine or its salt form for Mycotic Infections | Pat No: 332264 App No: 1186/CHE/ 2013 | 1. Dr. Karri V V S Narayana Reddy2. Dr. R.SureshKumar3. Dr. Rajkumar Malayandi4. Dr. Gowthamarajan Kuppusamy | Pharmaceutics | Filed: 20.03.2013Published: 21.08.2015Granted: 18.02.2020 | Awarded | JSS College of Pharmacy |
| 2 | Naturally Derived water soluble fraction of Fenugreek mucilage and its uses thereof in the Preparation nanoparticles | 4445/CHE/2012 | 1. Dr. Deepa Patahk2. Dr. K.Gowthamarajan3. Dr. Ankur Gupta4. Dr. Bhagyasree Kamble5. Dr. Elango Kannan | Pharmaceutics | Filed: 25.10.2012Published: 22.04.2016Granted: 17.12.2020 | Awarded | JSS College of Pharmacy |
| 3 | Encapsulated drug admixture composition for brain targeting via intranasal route. | 201741025232 | 1. Dr. K.Gowthamarajan2. Kousalya S | Pharmaceutics | Filed: 17.07.2017Published: 18.01.2019 | FER Submitted | JSS College of Pharmacy, Udhagamandalam (Off Campus College of Jagadguru Sri Shivarathreeswara University, Mysuru) |
| 4 | Tissue engineered acellular scaffold for the treatment of diabetic wounds | 202041027368 | 1. Dr. Karri V V S Narayana Reddy2. Mr. Bharat Kumar Reddy Sanapalli3. Ms. Rishita Tyagi4. Dr. Gowthamarajan Kuppusamy5. Dr. Praveen Thaggikuppe Krishnamurthy6. Dr. Ashish Devidas Wadhwani | Pharmaceutics | Filed: 27.06.2020Published: 30.10.2020 | Filed | JSS College of Pharmacy, Ooty JSS Academy of Higher Education & Research, Mysuru |
| 5 | Nanocarrier based Improved Blood Brain Barrier Penetration and Combinatorial Delivery of Anti-Retro Viral Drugs | 202041032882 | 1. Dr. Senthil Venkatachalam2. Dr. Nila Mary Varghese3. Dr. Jawahar Natarajan | Pharmaceutics | Filed: 31.07.2020Published: | Filed | JSS Academy of Higher Education and Research |
| 6 | Donepezil loaded lipid coated Naoceria for effective management of Alzheimer’s disease | 202041055661 | Dr. N. Jawahar Dr.S.Jubie Dr.S.P.Dhanabal | Pharmaceutics | Filed: 21.12.202 0 | Filed | JSS College of Pharmacy, Ooty- JSS Academy of Higher Education & Research, Mysuru |
| Sl. No. | Title of the Project | Name of the funding agency and fellowship |
|---|---|---|
|
8 |
Melt in mouth gelatin matrix |
Ceutics Lab, USA |
|
9 |
Effective management of multifactorial Alzheimer’s disease: An attempt of nanostructured lipid carriers containing Donepezil and curcumin through Olfactory to brain |
DST-SERB, JRF |
|
10 |
Development of suitable nanocarrier based drug delivery system for the better management of Alzheimer’s disease |
UGC, Maulana azad scholarship |
|
11 |
Novel nanoparticulates for targeted delivery to brain for management of epilepsy |
CSIR-Fellowship |
|
12 |
Young scientist Fellowship |
Tamilnadu state council for science and technology |
|
13 |
Artesunate and adjuvant loaded lipid based nanoemulsion as a combined therapy to improve efficacy in resistance: Formulation approach in the treatment of malaria |
Junior research scholarship (LADY TATA Memorial trust-Scientific research scholarship) |
|
14 |
Investigation of the therapeutic potential of capacitabine linked to the novel peptides binds to breast cancer. |
ICMR - Senior research fellow |
|
15 |
Intraductal administration of GLUT-1 inhibitor decorated metformin loaded carboxymethyl chitosan nanoparticles for targeted breast cancer therapy |
Indian council of Medical Research,(ICMR) New Delhi |
|
16 |
Dual lipid drug and flavinoids conjugates- a possible synergic strategy to address colon carcinoma cell |
Indian council of Medical Research,(ICMR) New Delhi |
|
17 |
Dual drug loaded biometric collagen chitosan hybrid nano composite scaffold for ameliorating tissue regeneration in diabetic wounds |
Indian council of Medical Research,(ICMR) New Delhi |
|
18 |
Management of Diabetic foot ulcer using collagen chitosan acellular dermal matrix integrated with nano anti- microbial |
Indian council of Medical Research,(ICMR) New Delhi |
|
19 |
Formulation and Evaluation of nanoparticles for the management of breast cancer |
JSS AHER- SRF Fellowship |
|
20 |
Management of Diabetic foot ulcer using collagen chitosan acellular dermal matrix integrated with nano anti- microbial peptide. |
SS AHER- SRF Fellowship |
|
21 |
Study on Influsence Gentic Polymersom effect on Ddabigatran etexilate in south India Populaion |
JSS AHER- SRF Fellowship |
|
22 |
Study on Influsence Gentic Polymersom effect on Ddabigatran etexilate in south India Populaion |
JSS AHER- SRF Fellowship |
|
23 |
Statin nanofibers coated with silver nanoparticles with angiogenic and antibacterial properties for enhancing diabetic wound healing associated with infections |
Indian council of Medical Research,(ICMR) New Delhi |
|
24 |
Biodirected Green Synthesis of cerium oxide nano particles for enhanced anti - oxidant property in the effective managment of Alzheimer disease |
Indian council of Medical Research,(ICMR) New Delhi |
|
25 |
Bio - specific silk fibroin mediated surface engineered nanostructured lipid carriers: A double sword approach to target epithelial overian cancer cells |
Indian council of Medical Research,(ICMR) New Delhi |
|
26 |
Formulation and Evaluation of Natural Compound Loaded Nanoparticles for Effective Treatment of Alzheimer’s Disease |
Quality Improvement Program, AICTE |
|
27 |
Injectable self-healing hydrogels of Celecoxib to potentiate the angiogenesis and supress the inflammation and infection associated with diabetic wounds |
AICTE NDF |
| Collaborator | National/ International |
|---|---|
| International Medical University, Malaysia | International |
| University of Technology Sydney, Australia | International |
| University of free state, South Africa | International |
| Macquarie University, Australia | International |
| Lovely Professional University, Punjab | National |
| Fortis Hospital, Punjab | National |
| NIPER, Hyderabad, India | National |
Centre of Excellence in Nanoscience & Technology", JSS Academy of Higher Education & Research promoted advanced and interdisciplinary research activities with industries and research institutions."
The centre collaborates with the University of Newcastle, Australia for a sustainable research "Plastics and People: Human health implications of Microplastics in the environment".Dr. Thava Palanisami, Prof. Richard Bush from the University of Newcastle, Australia and Dr. Gowthamarajan Kuppusamy, Dr. Praveen T K, Dr. Jawahar Natarajan from JSS Academy of Higher Education & Research are associated with this sustainable research.. This project emphasizes the potential environmental risks associated with the increased detection of microplastic based emerging contaminants in the ecosystem. This highlights the necessity of monitoring and ecological risk assessment of the effluent quality discharged from treated wastewater management system. Bilateral collaboration leading to exchange of technical knowledge and impactful research publications are the outcome of this collaborative research. This project is expected to impact Central Pollution Control Board , State and Central government in facilitating policy decisions, and control measures
The next notable research is "Design and development of prototype topical nano-based Terbinafine HCl gel: revalidation, risk assessment, and bioefficacy" , with an objective of designing a novel cost effective dosage form for allylamine antifungal to increase its penetrability with reduce the treatment time for a better patient compliance .
Collaborative research in association with Pharma solution India, for the project "Nano Formulation development palbociclib & Ixazomib" has encouraged industrial collaboration , translating the lab research to potential product development .
The center published a review article "Bite-sized review on an advance delivery system, support in the management of covid-19" in the journal International Journal of Research in Pharmaceutical Sciences in 2020. Furthermore, the center promotes collaborative publication in reputed , impactful journals in association with Lovely Professional University, Punjab; International Medical University, Malaysia; University of a free state, South Africa; University of Technology Sydney, Australia; Fortis Hospital, Punjab; NIPER, Hyderabad, India; Macquarie University, Australia.
The center continues in advancing the research in colon targeted minitablets, sliver nanoparticle, nano-formulation of a prodrug of sulfapyridine drugs and formulations for treating rheumatoid arthritis, ulcerative colitis, diabetic neuropathy , and continues to publish the research in journals with impact factor ranging from 2.734- 5.88. The centre also promoted herbal drug formulation and has developed Nano ocular delivery of herbal based product for the treatment of glaucoma. Copper oxide Nanoparticle disinfectant spray for the management of viral infection is under progress.
Two scientific presentations were made based on the research "Affibody decorated Solid Lipid Nanoparticles for Colorectal Cancer" in KMSO 2019-12th Annual Meeting of Korean Society of Medical oncology held in Seoul, South Korea by Dr. K Gowthamarajan. A research work "Curcumin Nanogel for the Treatment of Diabetic Retinopathy" was presented at CRS Conference 2020, Roseman University, USA by Mr. Arun Radhakrishnan.
Activity ReportDr. S P Dhanabal, Principal
Dr. Raman Suresh Kumar, Associate Professor, Dept. of Pharmaceutics
Dr. Natarajan Jawahar, Associate Professor, Dept. of Pharmaceutics
Dr. K Gowthamarajan, Head & Professor, Dept. Of Pharmaceutics
Dr. V Senthil, Professor, Dept. Of Pharmaceutics
Dr. GNK Ganesh, Associate Professor, Dept. Of Pharmaceutics
Dr. T K Praveen, Professor & Head, Dept. of Pharmacology
Dr. S N Meyyanathan, Professor, Dept. of Pharmaceutical Analysis.
Dr. Rajesh Kumar R, Lecturer, Dept. of Pharmaceutical Biotechnology.
Dr. VVS Narayana Reddy, Assistant Professor, Dept. Of Pharmaceutics
Dr. N Ponpandian, Professor & Head, Dept. of Nanoscience and Technology, Bharathiar University, Coimbatore.
Dr. Rajesh Kannan, Scientist ‘D’, Molecular & Nanomedicine Research Unit, Center for Nanoscience & Nanotechnology, Sathyabama University, Chennai.
Dr. V Shankar, Head & Professor, Dept. of Pharmaceutics, PSG college of pharmacy, Coimbatore
Dr. S Kumar, Head of Formulation and Analytical research team, KMS Health Center, Chennai.
Mr. Jerin Vincent, First Century, Associate Director FRD, Pharmaceuticals PVT Ltd
Mr. k Selvakumar, Chief Operating officer, Theragen Life Sciences
Dr. Raman Suresh Kumar
E-mail ID: sureshcoonoor@jssuni.edu.in
Ph. No.: +91 9865064872
Dr. Natarajan Jawahar
Email Id: jawahar.n@jssuni.edu.in
Ph. No: 9486946314