Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR)
Since its inauguration by Sri. Sudip Bandyopadhyay, former Union Minister of State for Health and Family Welfare, Government of India, on 6th July 2012, the Centre of Excellence in Molecular Biology and Regenerative Medicine (CEMR) located in the Department of Biochemistry, JSS Medical College, has made significant contributions in the field of biomedical research, promoted student and teacher training, and produced high-quality researchers and published research and review articles. Currently, the CEMR is supported by JSS Academy of Higher Education & Research and the funds received in part by Vision Group on Science and Technology (VGST), Government of Karnataka and Department of Science and Technology - Fund for Improvement of Science and Technology Infrastructure (DST-FIST) program.
VISION
To have a cross-disciplinary, multipronged approach to diagnose and treat various diseases and bridge the distance between clinical and laboratory research using molecular biology and stem cells research
MISSION
The mission of the "Center of Excellence in Molecular Biology and Regenerative Medicine" (CEMR) is
- To help develop diagnostic techniques and novel therapies using molecular biology and stem cell technology
- To pursue understanding the mechanisms for various diseases and therapies through molecular biology
- To offer academic programs and training in the area of molecular biology and biomedical research to help develop skilled manpower
- To establish a human bio-repository for archiving clinically annotated specimens
Objectives
- Develop biomarkers for early diagnosis and detection of various diseases Develop biomarkers for early diagnosis and detection of various diseases
- Identify therapeutic and drug resistance markers in various communicable and non communicable diseases
- To identify key factors regulating cellular transformation and differentiation in health and disease.
- To promote "stem cell based research" for developing diagnostic techniques and novel therapies for various otherwise difficult to treat diseases
- To assist drug discovery using molecular biology
- To conduct training and academic programs
Research Facilities Available
Research Activities that can be carried out using the facilities available at CEMR lab
- Drug design and discovery using molecular biology
- Development of biomarkers for early diagnosis and detection of various diseases
- Development of phytochemicals and nutraceuticals targeting specific pathway for the prevention and treatment of diseases
- Identifying the molecular basis of development and pathogenesis of diseases such as metabolic syndrome, diabetes, nonalcoholic fatty liver disease and cancer (breast cancer, colorectal cancer, cervical cancer, liver cancer and HPV associated cancer).
- Understanding the pathophysiology of environmental diseases such as respiratory and cardiovascular diseases
- Developing in-house diagnostic tools for the early detection of pathogens causing sepsis.
Equipments/Instruments available
| Sl.No. | Particulars | Company |
|---|---|---|
| 1 | Microplate Reader & Immunowash | Biorad |
| 2 | Stirred water bath TS 4 MS-W.B. | Genetix (Taurus scientific) |
| 3 | PCR machine Master cycler gradient part # 5331000010 | Eppendorf |
| 4 | Shaker incubator Excella E24R part # M 13520006 | Eppendorf (New Brunswick) |
| 5 | Micro pipettes | Eppendorf |
| 6 | -860C Freezer U9440-0001 model u725-Innova | Eppendorf (New Brunswick) |
| 7 | Olympus Inverted microscope with stereo zoom camera and disective microscope | Olympus |
| 8 | CO2incubator Cat no: 7BZ-HF160W-001 | Heal-Force |
| 9 | Western blot unit Cat no: MEBM-10 | Major Science |
| 10 | Gel electrophoresis unit with power pack | Hoefer |
| 12 | Water purification system | Merck - Millipore |
| 13 | Flake Ice Maker 90 KG/Day | Labindia (Skadi -Enrope) |
| 14 | U V Transilluminator | Medispec India Ltd. (MIL) |
| 15 | High speed refrigerated centrifuge | Eppendorf |
| 16 | Bio spectrometer | Eppendorf |
| 17 | Bio safety cabinet | Esco biotech pvt ltd |
| 18 | Laboratory Refrigerator | Cryo scientific systems (pvt) limited |
| 19 | Liquid nitrogen vessels | M/s De-luxe trading company |
| 20 | Gel dryer system | M/s Bio-rad lab pvt. ltd |
| 21 | Gel documentation system | Syngene |
| 22 | Lyophilizer | Labmate |
| 23 | Micro Centrifuge tubes | Tarsons |
| 24 | -200C freezer | Cryo scientific systems (pvt) limited |
| 25 | MACS unit & gentle tissue dissociator | Miltenyi Biotec |
| 26 | Micro centrifuge - knob version | Eppendorf |
| 27 | Auto clave | Medica instrument MFG co. |
| 28 | Vacuum 4 bar pump | Biolix technologies |
| 29 | Multimode plate reader | Perkin elmer |
| 30 | Upright Microscope fluorescent | Olympus |
| 31 | High performance liquid chromatography | Shimadzu |
| 32 | RT-PCR | Qiagen |
| 33 | Weighing Balance | Kumar diagnostics & surgicals |
| 34 | Refrigerated Centrifuge | Hettich Zentuifugen |
| 35 | Block Heater | Staurt |
| 36 | Thermomixer C | Eppendorf |
| 37 | Seven Campart PH meter S210 (3 units) | M/s Mettler |
| 38 | Multispin (1 unit) | Tarsons |
| 39 | Spinix (2 unit) | Tarsons |
| 40 | Spinwin (2 unit) | Tarsons |
| 41 | Centrifuge 5424R (Refrigerated) | Eppendorf |
| 42 | Sonicator | PCI Analytics |
| 43 | Sampler Envirotech APM550MFC | Envirotech Instruments Pvt Ltd |
| 44 | Labnet incubater shaker | Labnet |
| 45 | Micro wave oven | LG |
| 46 | Mixer grinder | Preethi |
| 47 | UV spectrometer with nano-drop | Eppendorf |
| 48 | 40C-refrigerator | Thermofischer |
| 49 | Shaking Water Bath | Julabo |
| 50 | Biological Safety Cabinet | Thermofischer |
| 51 | Air Jacketed CO2 Incubator | Thermofischer |
| 52 | General Purpose water baths | Thermofischer |
| 53 | Weighing Balance | Shimadzu |
| 54 | Thermocycler | Takara |
| 55 | Electrophoretic Unit | Bio BeetM |
| 56 | Air jacketed CO2incubator | Thermo Scientific |
| 57 | Concentrator unit (speed vac) | Eppendorf |
| 58 | Semi Auto analyzer (Mispa Viva) | Agappe |
| 59 | Glucometer | MAX |
| 60 | Centrifuge (C ZBKN-30226) | REMI |
| 61 | Centrifuge (C ZDHN-20821) | REMI |
| 62 | Gel Documentation System | UV Tech |
| 63 | Inverted Microscope | Laben |
| 64 | Ice Flaker | Blue star |
| 65 | Micro Centrifuge | Spark palm |
| 66 | Vortex Mixer | JJ Biotek |
| 67 | 4”C Refrigerator | Celfrost |
| 68 | Incubator | KEMI |
| 69 | Micro volume spectrometer nano drop | J H Bio |
| 70 | Thermo Scientific Forma 900 series upright single door freezer (-800C) | Thermo Scientific |
| 71 | Thermo Scientific Multiskan GO without curette 100-240V, 50/60 Hz (microplate spectrometer) | Thermo Scientific |
| 72 | Victror 2D Multilable Counter | Perkin Elmer |
| 73 | DELFIA(R) washer | Perkin Elmer |
| 74 | DELFIA plateshaker | Perkin Elmer |
| 75 | DBS puncher | Perkin Elmer |
| 76 | TriNESTTM microplate incubator shaker | Perkin Elmer |
| 77 | Himac micro ultracentrifuge, Leica confocal microscope. | |
| 78 | LC MS | |
| 79 | Flow cytometer |
Approved Research Guides
Ongoing PhD Thesis and Fellowships
Scholar: Deepthi V
Title: Role of circadian rhythm genes in colorectal cancer
Guide: Dr. Akila Prashant
Scholar: Deepashree V S
Title: Short-chain fatty acids in modulating air pollutants-induced pulmonary and systemic inflammatory responses
Guide: Dr. Rajesh Kumar T
Co-Guide: Dr. M.V.S.S.T.SubbaRao
Fellowship/Financial support: DST-INSPIRE JRF
Scholar: Anju S
Title: Newborn screening for spinal muscular atrophy and identification of novel mutations
Guide: Dr. Prashant Vishwanath
Scholar: Ms. Kavitha B C
Title: Prevalence of extra-intestinal pathogenic Escherichia coli (E. coli) to determine disease severity and antibiotic sensitivity among women with type-2 diabetes and urinary tract infection in India.
Guide: Dr. Mahesh P A
Co-Guide: Dr. MVSST SubbaRao
Scholar: Medha Karnik S R
Title: Characterization of cervico - vaginal microbiome and metabolites involved in pathogenesis of cervical cancer
Guide: Dr. MVSST SubbaRao
Co-Guide: Dr. Vijaya B
Fellowship/Financial support: Prime Minister's fellowship for Doctoral Research/ SRF
Scholar: Mr. Sumit Kumar Dey
Title: Elucidation of proteasome dysfunction and ER stress in the pathogenesis of lung injury exposed to urban air pollutants
Guide: Dr. Rajesh Kumar Thimmulappa
Fellowship/Financial support: DBT/ Project Assistant
Scholar: Mr. Anshu kumar Yadav
Title: Novel in-house multiplex PCR guided management of neonatal sepsis in tertiary care hospital in a South-India
Guide: Dr. M N Suma
Fellowship/Financial support: ICMR/SRF
Scholar: Mr. Pushkal S R
Title: Elucidation of NRF2 signaling pathway in molecular pathogenesis of Human Papillomavirus associated Head and Neck Squamous cell carcinoma
Guide: Dr. Devananda D
Fellowship/Financial support: CSIR/JRF
Scholar: Ms. Souparnika H M
Title: Development of phytochemical activators of NRF2 signaling for mitigation of environmental lung disease
Guide: Dr. Rajesh Kumar Thimmulappa
Fellowship/Financial support: DST/JRF
Scholar: Dr. Swetha N K
Title: To investigate the association of HDL mediated reverse cholesterol transport, antioxidant and anti-inflammatory function with coronary disease occurrence in diabetic patients
Guide: Dr. Rajesh Kumar Thimmulappa
Fellowship/Financial support: Part Time, DBT/PI
Scholar: Mr. Chinnappa A U
Title: Assessing the role of NRF2 in vitamin D deficiency induced congenital dysfunction in type-II diabetes
Guide: Dr. MVSST SubbaRao
Fellowship/Financial support: DST/SRF
Scholar: Ms. Kavya Sugur
Title: Oxidized phospholipids & Lipoprotein (a) as a predictor of severity of coronary artery disease in diabetic patients
Guide: Dr. Rajesh Kumar Thimmulappa
Fellowship/Financial support: ICMR/SRF
Scholar: Ms. Veena R
Title: Discovering Phytochemicals for promoting longevity and healthy ageing using Drosophila model
Guide: Dr. Rajesh Kumar Thimmulappa
Fellowship/Financial support: ICMR/SRF
Scholar: Ms. Vidya B G
Title: Use of NRF-2 regulated circulating micro RNA as non- invaslve biomarkers in breast cancers
Guide: Dr. MVSST SubbaRao
Fellowship/Financial support: DST/Project Assistant
Scholar: Mr. Mahadevaswamy K G
Title: Comparative assessment of phenolic compounds, extracted from millets, for inhibiting the growth of colorectal and breast carcinomas
Guide: Dr. MVSST SubbaRao
Fellowship/Financial support: ICMR/SRF
Scholar: Ms. L H Zonunsiami
Title: Functional characterization of Nrf2 in Colorectal Carcinoma
Guide: Dr. MVSST SubbaRao
Fellowship/Financial support: NFST/JRF
Scholar: Mrs. Lavanya B R
Title: Understanding the role of Vitamin D on Glomerulus basement membrane constituents during Diabetic Nephropathy
Guide: Dr. Akila Prashant
Fellowship/Financial support: DST/Project Assistant
Scholar: Mr. Adel Mohammed Saleh Ahmed
Title: Association of gene polymorphism in obesity related genes and insulin resistance with the risk of colon and breast cancer
Guide: Dr. Akila Prashant
Scholar: Dr. Shobha C R
Title: “DNA methylation status of genes regulating adipogenesis (PPARy, CEBPA, SREBF1) and correlation of gene expression and cardio-metabolic parameters among young adults”
Guide: Dr. Prashant Vishwanath
Fellowship/Financial support: Part Time
Scholar: Ms. Brunda A
Title: “Anti-Cancer activity directed isolation & characterization of venom biomolecules from jelly fish found in the west coast of India”
Guide: Dr. Devananda D
Fellowship/Financial support: Part time
Scholar: Nishitha R Kumar
Title: “Detection of antibiotic resistance pattern on clinical isolates Escherichia coli and Klebsiella pneumonia using multiplex PCR in the management of sepsis”
Guide: Dr. Akila Prashant
Fellowship/Financial support: JSSAHER
Scholar: Mohammed Kaleemullah
Title: “Mechanism of AGE’s induced alteration leading to cognitive impairment via intracellular signaling and Role of Bacopa monnieri”
Guide: Dr. Prashant Vishwanath
Fellowship/Financial support: DMKJ/JRF
Scholar: Akshatha N S
Title: “AATF as a Molecular Target for the Treatement of Nonalcoholic Fatty Liver Disease(NAFLD)”
Guide: Dr. Divya P Kumar
Fellowship/Financial support: DBT Ramalingaswami/ Project Assistant
Scholar: Siva Dallavalasa
Title: “Targeting key signalling cascades using D-Formin (A combination of Vitamin-D and Metformin) for inhibiting carcinomas of breast in vitro and in vivo”
Guide: Dr. MVSST SubbaRao
Fellowship/Financial support: DBT/SRF
Title PhD: Repurposing of anti-hyperglycaemic agents for inhibiting breast cancer cells growth in vitro and in vivo
Scholar: Chaithanya G B
Title: “Targeting key signalling cascades using D-Formin (A combination of Vitamin-D and Metformin) for inhibiting carcinomas of breast in vitro and in vivo”
Guide: Dr. MVSST SubbaRao
Fellowship/Financial support: DBT/ Project Assistant
Title PhD: Co-targeting key oncogene signalling cascades regulating breast cancer and development using vitamin D and anti-diabetic agents
Guide Name: Dr. MVSST SubbaRao
Scholar: Ms. Greeshma M V
Title: Chronic Respiratory disease Innovation and Solution Program (MLP-126)
Guide: Dr. MVSST SubbaRao
Fellowship/Financial support: CSIR-IICB/ Project Assistant
Scholar: Mr. Tulimilli Venkata Subba Rao
Title: Up regulation of Hydroxy Prostaglandin Dehydrogenase (HPGD) expression using Hydroxy chloroquine as a novel therapeutic strategy in carcinoma cervix
Guide: Dr. M N Suma
Fellowship/Financial support: ICMR/JRF
Scholar: Varsha Dilip Shiragannavar
Title: The role of RNA-induced silencing complex in the development and progression of non-alcoholic steatohepatitis & Hepatocellular Carcinoma: The molecular intervention using natural compounds
Guide Name: Dr. Prasanna Kumar S
Fellowship/Financial support: DBT Ramalingaswamy/ Project Assistant
Scholar: Nirmala G S
Title: To study the crosstalk between liver adipose tissue and heart in metabolic syndrome
Guide Name: Dr. Prasanna Kumar S
Scholar: Supriya Bevinakoppamath
Title: Role of circadian rhythm genes in breast cancer
Guide Name: Dr. Akila Prashant
Scholar: Vinod Kumar V R
Guide: Dr. Prashant Vishwanath
Title: “Demographic profiling, evaluation of genetic variations and inflammatory biomarkers in a fluoride exposed population of south India”
Fellowship/Financial support:Part time
Scholar: Shruthi G
Guide: Dr. Prashant Vishwanath
Title: "Antihyperlipidemic effects (or Bio-attributes) of permuted essential oils: an in vitro and in vivo study"
Fellowship/Financial support:Part time
Scholar: Diwakar S
Guide: Dr. Divya Prasanna Kumar
Title: "Assessing the mechanistic role of AATF in hepatocellular carcinoma"
Fellowship/Financial support:Full time
Scholar: Narasimha Murthy Beeraka
Guide: Dr. MVSST SubbaRao, Professor Department of Biochemistry, JSSMC
Co Guide: Dr. Sujatha P, Assistant Professor, Department of Biochemistry, JSSMC
Title: "Targeting NRF2 glycation through FN3K inactivation using novel small molecule inhibitors for the treatment of carcinomas of breast in vitro and in vivo"
Fellowship/Financial support:Full time
Scholar: Priyanka M K
Co Guide: Dr. M.V.S.S.T. SubbaRao
Title: "Prognostic potential of matrix metalloproteinase-9 (MMP 9) and interlukin-8 (IL-8) in monitoring the treatment efficacy of anti breast cancer therapy "
Fellowship/Financial support:Full time
PhD Awarded
Scholar: Mr. Anshu kumar Yadav
Title: Novel in- house multiplex PCR guided management of neonatal sepsis in tertiary care hospital in a South-India
Guide: Dr. M N Suma, Professor of Biochemistry, JSSMC
Co-Guide: Dr. Narayanappa D, Professor, Department of Pediatrics, JSSMC
Scholar: Mr. Pushkal S R
Title: Elucidation of NRF2 signaling pathway in molecular pathogenesis of Human Papillomaviru s associated Head and Neck Squamous cell carcinoma
Guide: Dr. Devananda Devegowda, Assistant Professor, Department of Biochemistry, JSSMC
Co-Guide:Dr. Rajesh Thimmulappa, Associate Professor, Department of Biochemistry, JSSMC
Scholar: Mr. Mahadevaswamy K G
Title: Comparative assessment of phenolic compounds, extracted from millets, for inhibiting the growth of colorectal and
Guide: Dr. MVSST SubbaRao, Professor, Department of Biochemistry, JSSMC
Co-Guide:Dr. Rajesh Thimmulappa, Associate Professor, Department of Biochemistry, JSSMC
Scholar: Ms. Souparnika H M
Title: Development of phytochemical activators of NRF2 signaling for mitigation of environmental lung disease
Co-Guide:Dr. Rajesh Thimmulappa, Associate Professor, Department of Biochemistry, JSSMC
Guide: Dr. MVSST SubbaRao, Professor, Department of Biochemistry, JSSMC
Scholar: Dr. Thippeswamy H M
Title: A study to determine the effect of fluoride in drinking water on calcium, vitamin D and associated hormones in pregnant women and their newborns (Does fluoride content in drinking water affect the serum calcium, phosphate and its associated hormones-vitamin D & parathyroid hormone in pregnant women and newborn infants? )
Guide: Dr. Devananda D
Scholar Name: Mr Shashank K Prasad
Title: Bioactivity directed fractionation of annoona muricata for the charectrization of anti breast cancer aagents
Guide Name: Dr. Devananda D, Assistant Professor, Department of Biochemistry, JSSMC
Co-Guide Name:Dr M N Suma, Professor & HOD of Biochemistry Dept , JSSMC
Scholar Name: Mr Prashanth Kumar M V, SRF- ICMR
Title: In Vitro evaluation of Anti-Cancer effect of Vitamin D3 alone and in combination with Anti diabetic compound Metformin
Guide Name: Dr M N Suma, Professor & Head, Dept of Biochemistry, JSSMC
Co-Guide Name:Dr. M.V.S.S.T. SubbaRao, Associate Professor, Dept of Biochemistry, JSSMC
Scholar Name: Mr. Venugopal Reddy, SRF- ICMR
Title: Assessing the role of NRF2 in Breast Cancer
Guide Name: Dr. MVSST SubbaRao, Professor, Department of Biochemistry, JSSMC
Co-Guide Name:Dr. G V Manjunath, Professor of Pathology , JSSMC
Scholar Name: Ms. Jhansi Lakshmi M
Title: Evaluation of FVIIa-EPCR interactions in the management of hemophilic arthroplasty
Guide Name: Dr. MVSST SubbaRao, Professor, Department of Biochemistry, JSSMC
Co-Guide Name:Dr. L Vijay Mohan Rao
Scholar Name: Dr. M.K. Jayanthi
Title: Screening and identification of Nrf2 inhibitors from natural products for the treatment of lung cancer
Guide Name: Dr. M.V.S.S.T.SubbaRao
Year of Awarding: 2017
Scholar Name: Dr Prashant V
Title: A clinical & experimental study to evaluate the anti-diabetic effect of Momardia charantia (Bitter Gourd) & study the effects of gene expression
Guide Name: Dr H Basavanagowdappa
Year of Awarding: 2018
Scholar Name: Mrs. P. Sujatha
Title: Development of nanotherapeutic anti-cancer agents from garlic for the treatment of breast carcinoma
Guide Name: Dr. M.V.S.S.T.SubbaRao
Year of Awarding: 2018
Scholar Name: Mr Manish Kumar Yadav
Title: Evaluation of Chromosome21 changes followed by Vitamin B12 & Folic acid deficiency in the Megaloblastic Bone marrow
Guide Name: Dr Nandish S Manoli
Year of Awarding: 2017
Scholar Name: Ms Preethi
Title: Chemopreventive Phytochemicals from Momardica diosia for Prostate cancer
Guide Name: Dr G V Manjunath
Year of Awarding: 2017
Scholar Name: Mrs. B.S. Anjali Devi
Title: Identification and characterization of deregulated genes for the diagnosis and treatment of cervical cancer
Guide Name: Dr. M.V.S.S.T.SubbaRao
Year of Awarding: 2018
Scholar Name: Dr. C. Prathima
Title: Characterization of naturally occurring nrf2 inhibitors for the treatment of colorectal cancer
Guide Name: Dr. M.V.S.S.T.SubbaRao
Year of Awarding: 2019
