Scientific Services

With cutting edge technologies in scientific research along with wide range of experienced professionals, CPT alliances with its partners to bring forth endless variety of disease models and preclinical services in the following areas

  • Pharmaceuticals
  • Medical devices
  • Agrochemicals and Pesticides
  • Food products and Nutraceuticals
  • Folklore Remedies

Pharmacokinetics by various routes viz., oral, intravenous and subcutaneous in mouse models in (SAM, Balb/C), rats (Wistar, Sprague Dawley)

  • Tissue Distribution
  • Brain to Plasma Ratio

CPT have validated animal models on

  • Alzheimer's and Parkinson's disease (Chemical and ICV surgical model)
  • Cerebral stroke (middle cerebral artery, 2/4 vessels occlusion surgical models)
  • Depression (Chemical and behavioral CUMS models)
  • Epilepsy (Chemical and ICV surgical models)
  • Gastric ulcer (Surgical, chemical models)
  • Diabetes (Chemical, diet and genetic models)
  • Hepatic diseases (Drugs and chemical models)
  • Pain and Inflammation models (carrageenan, cotton pellet granuloma, formalin and acetic acid models) )
  • Nootropics (radial arm maze, passive avoidance, transfer latency)
  • Rheumatoid arthritis (FCA model)

Toxicology is a highly eclectic branch of medical science that deals with study of toxic / adverse effects of chemicals, biologics in living systems. This branch of science serves the society in many ways by not restricting to protect humans and the environment from the deleterious effects of toxicants but also to facilitate the development of newer drugs. CPT is approved (license no: 155/PO/Re/S/1999/CPCSEA) by Committee for the Purpose of Control and Supervision of Experimentation on Animals (CPCSEA), Ministry of Environment and Forests, Government of India, to conduct experiments on animals (rodents, guinea pigs, rabbits)

Test Systems

  • Mouse
  • Rat
  • Guinea-pig
  • Rabbit

Routes of Exposure

  • Oral
  • Dermal
  • Intra Nasal

Toxicology studies are performed in accordance to the following guidelines:

  • Organization for Economic Co-operation and Development (OECD)
  • Schedule Y
  • ISO (Medical devices)

Acute Toxicity

Single / Two species (rodent and non-rodent), Observations for 14 days, Clinical and gross morphological effects

  • Acute Oral Rat Limit Test
    Preview
  • Acute Dermal Toxicity
    Preview
  • Primary Dermal Irritation Rabbit Study
    Preview
  • Primary Ocular Irritation Rabbit Study
    Preview
  • Guinea Pig Dermal Sensitization Study
    Preview

Sub-Acute / Sub-Chronic toxicity

Single / Two species (rodent and non-rodent), three dose levels plus controls and satellite groups, clinicopathological, gross and histopathological examinations

  • 14 / 28 / 90 - day oral gavage rat study

Chronic Toxicity

Two species (rodent and non-rodent), daily dosing via clinical route, three dose levels plus controls, satellite groups, clinicopathological, gross and histopathological examinations

  • Cellular assays

    Cytotoxicity assays using human / animal cell lines

  • Molecular biology

    Single target protein or co-localisation, cytokines expression, oxidative stress markers expression, TUNEL assay, double immunofluorescence assays

  • Histopathology and Immunohistochemistry

    Fixing, trimming, embedding, sectioning and staining tissues. Special requirements with selective staining or immunohistochemical also performed

  • Biochemical assays

    ELISA and fluorescence assays, inflammatory markers, cell membrane markers, oxidative stress markers and anti-oxidant proteins such as superoxide dismutase, catalase, glutathione, etc.